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Norditropin is a prescription somatropin injection manufactured by Novo Nordisk that contains a recombinant human growth hormone identical in structure to natural human growth hormone.
Norditropin by Novo Nordisk is a widespread treatment for growth hormone deficiency. Hormones play a crucial part in the way the body works. Each hormone has a particular job to do, and a unique reason for doing that job.
Hormones travel to the designated tissue or organ via the bloodstream to send the message they were designed to send to make the bodywork better. The growth hormone, naturally created in the pituitary gland, enables the body to grow.
The human growth hormone also assists the body through certain metabolic processes. It sends a signal to the liver to release another hormone, namely IGF-1. Together IGH-1 and growth hormone work to tell the cells in bones, muscles, organs, and tissues to develop and grow.
Why do adults use Norditropin
Norditropin injections should be used by adults with growth hormone deficiency. More specifically, HGH injections may be recommended for adults who:
- Have growth hormone deficiencies
- Have pituitary disease
- Have hypothalamic disease
- Were growth hormone deficient as children due to congenital, idiopathic or acquired reasons
Norditropin is available by prescription only
Key Uses
- Pediatric Growth Failure: Treats children with growth hormone deficiency (GHD), Noonan syndrome, Turner syndrome, Prader-Willi syndrome, idiopathic short stature (ISS), or children born small for gestational age (SGA) with no catch-up growth.
- Adult Growth Failure: Replaces missing growth hormone in adults with GHD.
How to use Norditropin pen. Dosage and Administration
The Norditropin pen makes it easy to get your daily shot. Here are some important points about it.
Norditropin Dosage
Your dosage will be determined by your prescribing physician. The dose may vary depending on lab results, weight, and response to the medication. It is very important to continue with all follow-up appointments with your physician to monitor progress and to allow for any adjustments that may be needed.
Norditropin is available in preloaded pens:
• 5 mg/1.5 mL (orange): Norditropin FlexPro pen
• 10 mg/1.5 mL (blue): Norditropin FlexPro pen
• 15 mg/1.5 mL (green): Norditropin FlexPro pen
• 30 mg/3 mL (purple): Norditropin FlexPro pen
Dosing for Adult patients either of two approaches to injection dosing may be followed: a non-weight-based regimen or a weight-based regimen.
Non-weight based — based on published consensus guidelines, a starting dose of approximately 0.2 mg/day (range, 0.15-0.30 mg/day) may be used without consideration of body weight. This dose can be increased gradually every 1 to 2 months by increments of approximately 0.1-0.2 mg/day.
According to individual patient requirements based on the clinical response and serum insulin-like growth factor I (IGF-I) concentrations. The dose should be decreased as necessary on the basis of adverse events and/or serum IGF-I concentrations above the age- and gender-specific normal range. Maintenance dosages vary considerably from person to person, and between male and female patients.
Weight-based — based on the dosing regimen used in the original adult GHD registration trials, the recommended dosage at the start of treatment is not more than 0.004 mg/kg/day. The dose may be increased to not more than 0.016 mg/kg/day after approximately 6 weeks according to individual patient requirements.
Clinical response, side effects, and determination of age- and gender-adjusted serum IGF-I concentrations should be used as guidance in dose titration.
Norditropin Administration
- The Norditropin FlexPro comes preloaded with medicine; no mixing required
- Always visually check that the medicine is clear in the window before administering your shot. If the window is anything but clear, notify your pharmacist or physician
- Open a needle and screw on to the end of the FlexPro pen
- It is necessary to prime the FlexPro pen before the first use by turning the dial one click and pushing the button. Repeat this process until a drop of medicine appears from the needle. You only have to do this before using the first time
- Choose your injection site and clean it with an alcohol pad. Norditropin is injected subcutaneously. Injection sites include the backs of the upper arm, the stomach area, buttocks, and thighs. Speak with your physician on which sites he or she would like for you to use
- Turn the dial on the pen until the dose prescribed by your doctor lines up with the arrow
- Insert the needle into the injection site as instructed by your health professional. It is important to rotate sites from one injection to the next
- Push on the button to dispense the medication, making sure that the dosage window shows zero
- Count slowly to six before removing the needle from your skin
- Make sure the needle is disposed of properly
Important Safety Information
- Contraindications: Do not use if you have active cancer, closed bone growth plates, diabetic retinopathy, critical illness from open heart or abdominal surgery, trauma, or severe breathing failure, or severe obesity/sleep apnea if you have Prader-Willi syndrome.
- Common Side Effects: Local injection site reactions, redness, rashes, and headaches.
- Serious Risks: High blood sugar (hyperglycemia), intracranial hypertension, fluid retention, decreased thyroid or cortisol levels, or slipped capital femoral epiphysis. Never share pens or needles.
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